Reconstitute ONLY with sterile water,2ml per vial,store in the fridge NOT the freezer.Once mixed it is meant for immediate research uses(within a few weeks),NOT long term storage.

Bremelanotide (PT-141) FAQ

What is Bremelanotide (PT-141)? By: TanResearch

Bremelanotide (formerly PT-141) is the generic term for a new medication for

use in treating sexual dysfunction in men (erectile dysfunction or

impotence) as well as sexual dysfunction in women (sexual arousal disorder).

It is a synthetic aphrodisiac. Unlike Viagra and other related medications,

it does not act upon the vascular system, but directly increases sexual desire.



Originally, the peptide Melanotan II that bremelanotide was developed from

was tested as a sunless tanning agent. In initial testing, Melanotan II did

induce tanning but additionally caused sexual arousal and spontaneous

erections as unexpected side effects in eight out of the ten original male

volunteer test subjects. In clinical studies, bremelanotide has been shown

to be effective in treating male sexual and erectile dysfunction as well as

female sexual dysfunction. It is currently being tested by Palatin Technologies.



Bremelanotide is a cyclic hepta-peptide lactam analog of

alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the

melanocortin receptors MC3-R and MC4-R in the central nervous system. It has

the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or

cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). PT-141 is a metabolite of

Melanotan II that lacks the C-terminal amide function. Its molecular formula

is C50H68N14O10 with a molecular weight of 1025.2.

In the United States it is currently in a Phase III clinical trial.



Are these nasal? Oral, Injectable?



Currently the nasal and oral routes have not been made efficient. PT-141 is

a sterile injectable made for sub-q injection, like insulin.



What's the dosing schedule...how much do I take?



1-2mg is the typical effective dose. Taking 2-4 hours before game time is ideal.



Say you had a dinner and movie arranged. Taking before dinner may be the

best route, however during the climax of the movie may interfere with one of

your own…read between the lines there



Is there any reconstituting involved?



Yes and bacteriostatic water is the recommended solvent here. To mix the

vial with bact water, take one syringe (BD Ultrafine II 1cc or 1/3 cc are

excellent and I recommend them) and grab your vial of bacteriostatic water.

If using a 1 cc syringe (100 units), use the syringe to withdraw 1 full ml

(1cc) and inject that into the vial of PT-141 through the rubber. Be sure to

aim the needle towards the glass, so that it will trickle down and not harm

the peptide. Swirl the vial to thoroughly mix and let the peptide dissolve.

The key here is to be gentle. Say you had the vial of PT-141 stored in the

freezer, move the vial of PT-141 to fridge for an overnight stay. Then you

are ready the next day to reconstitute the same temperature refrigerated

bact water with the PT-141 in the most efficient manner. Just some tricks of

the trade here.



So now you have 100 units (1cc) of bacteriostatic water mixed with 10 mg of

PT-141 in your vial ready to go. A 1mg dose would be 10 units or .1ml

(.1cc). Make sense? Hope so.



How is it stored?



The lyophilized powder (freeze dried state) can be stored in the freezer or

refrigerator. Once reconstituted (mixed with water) it will be good for a

month in the refrigerator before it begins to degrade.



Does this help give erections or just put you in the mood?



“With PT-141, you feel good, not only sexually aroused,” reported anonymous

patient 007, a participant in a Phase 2 trial, “you feel younger and more

energetic.” Said another patient: “It helped the libido. So you have the

urge and the desire. . . . You get this humming feeling; you’re ready to

take your pants off and go.” And another: “Twice my wife and I had sex twice

in one night. I came in [to work] and I just raved about it: ‘Jesus, guys .

. . 58 years old and you don’t do that.’ ” Tales of pharmaceutically induced

sexual prowess among 58-year-olds are common enough in the age of the Little

Blue Pill, but they don’t typically involve quite so urgent a repertoire of

humming, throbbing, tingling, and double-dipping. Or as patient 128 put it:

“My wife knows. She can tell the difference between Viagra and PT-141.”



The precise mechanisms by which PT-141 does its job remain unclear, but the

rough idea is this: Where Viagra acts on the circulatory system, helping

blood flow into the penis, PT-141 goes straight to the brain itself. And

there it goes to work, switching on the same neural circuitry that lights up

when a person actually, you know, wants to.



Basically this takes men back to middle school. You may find yourself in a

similar situation as you were in 8th grade science class with the teacher

bent over helping the student in front of you. It may be necessary to do a

“tuck up” if at the office…especially at the public pool!



Women state that the sensation given from injecting PT-141 is like being in

heat! One colleague in particular stated that she didn’t know what was going

on…but she had wanted “it” all day long after dosing the night before.